An efficient synthesis of some new 3-bipyridinyl substituted coumarins as potent antimicrobial agents
作者： Hemali B. Lad , Rakesh R. Giri , D.I. Brahmbhatt
DOI: 10.1016/J.CCLET.2013.01.041
关键词: Coumarin 、 Organic chemistry 、 Chemistry 、 Antimicrobial 、 Proton NMR 、 Reaction conditions 、 Combinatorial chemistry 、 Carbon-13 NMR
摘要: Abstract As a part of the ongoing studies in developing new antimicrobials, series structurally novel 3-bipyridinyl substituted coumarin derivatives 4a–f and 5a–f were synthesized by single-step reaction protocol under Krohnke's conditions. 1H NMR, 13C IR mass spectral techniques employed for structural elucidation compounds. An evaluation antimicrobial activity showed that almost all compounds exhibited better results than referenced drugs. Among 4f, 5a 5d found to be most potent analogs. Thus they could promising lead
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