The chemotherapy of onchocerciasis. XI. A double-blind comparative study of ivermectin, diethylcarbamazine and placebo in human onchocerciasis in northern Ghana.

摘要: Fifty-nine onchocerciasis patients with ocular involvement were randomly assigned to receive either 12 mg of ivermectin in a single dose or 1300 diethylcarbamazine over eight days matching placebo capsules. Detailed standardized follow-up examination was carried out for one year.Both and rapidly reduced skin microfilarial counts similar extent six months, after which increased significantly more diethylcarbamazine. Diethylcarbamazine eliminated microfilariae from the eye, while did so months. Reactions treatment severe diethylcarbamazine, also produced clinical deficiency two patients. Ivermectin intra-uterine sequestration degeneration adult worms, may account its ability produce prolonged suppression microfilariae. proved superior safety, tolerance efficacy, but further work is needed as...