Merlin: the wizard requires protein stability to function as a tumor suppressor.

摘要: Neurofibromatosis type 2 (NF2), characterized by tumors of the nervous system, is a result functional loss NF2 gene. The gene encodes Merlin (moesin–ezrin–radixin-like protein), an ERM (Ezrin, Radixin, Moesin) protein family member. functions as tumor suppressor through impacting mechanisms related to proliferation, apoptosis, survival, motility, adhesion, and invasion. Several studies have summarized intrinsic mutations in Merlin. Given fact that cells are not isolation, but rather intricate, mutually sustaining synergy with their surrounding stroma, dialog between stroma can potentially impact molecular homeostasis promote evolution malignant phenotype. This review summarizes epigenetic modifications, transcript stability, post-translational modifications We reviewed role extrinsic factors originating from milieu influence availability inside cell. Information regarding regulation could lead novel therapeutics stabilizing reduced expression without displaying any genetic alterations.