Relations between approved platinum drugs and non-coding RNAs in mesothelioma.
作者： Bernhard Biersack
DOI: 10.1016/J.NCRNA.2018.08.001
关键词: Long non-coding RNA 、 Cisplatin 、 Drug 、 Medicine 、 Pemetrexed 、 Gemcitabine 、 microRNA 、 Carboplatin 、 Mesothelioma 、 Cancer research
摘要: Malignant mesothelioma diseases feature an increasing risk due to their severe forms and association with asbestos exposure. Platinum(II) complexes such as cisplatin carboplatin are clinically approved for the therapy of often in combination antimetabolites pemetrexed or gemcitabine. It was observed that pathogenic properties cells response tumors towards platinum-based drugs strongly influenced by non-coding RNAs, particular, small microRNAs (miRNAs) long RNAs (lncRNAs). These controlled drug sensitivity development tumor resistance platinum drugs. An overview interactions between is given influence on efficacy discussed. Suitable RNA-modulating agents potentially beneficial effects treatment mentioned. The understanding concerning will optimize existing schemes pave way new options future.
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