Neoadjuvant Chemotherapy in Breast Cancer Patients Induces miR-34a and miR-122 Expression
作者： Pierre Frères , Claire Josse , Nicolas Bovy , Meriem Boukerroucha , Ingrid Struman
DOI: 10.1002/JCP.24730
关键词: Anthracycline 、 Cell 、 Cancer 、 Circulating MicroRNA 、 Immunology 、 Cancer research 、 Biology 、 Breast cancer 、 microRNA 、 Chemotherapy 、 MiR-122
摘要: Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we describe modifications circulating miRNAs profile after neoadjuvant chemotherapy (NAC) for breast cancer. The 188 was assessed plasma 25 patients before and NAC by RT-qPCR. Two miRNAs, miR-34a miR-122, that were significantly increased NAC, measured tumor tissue 7 with pathological partial response (pPR) to NAC. These two chemotherapy-induced further 22 adjuvant (AC) well 12 who did not receive any chemotherapy. Twenty-five modified Among these miR-122 highly upregulated, notably pPR aggressive Furthermore, level elevated remaining treatment. Studying kinetics during revealed levels especially anthracycline-based Comparisons miRNA profiles AC suggested originated from both tumoral non-tumoral compartments. This study first demonstrate specifically induces tissue, which might be involved anti-tumor effects patients. J. Cell. Physiol. 230: 473–481, 2015. © 2014 Wiley Periodicals, Inc.
sci-hub.se 参考文章(51)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Petr L. Jedelský, Pavel Doležal, Petr Rada, Jan Pyrih, Ondřej Šmíd, Ivan Hrdý, Miroslava Šedinová, Michaela Marcinčiková, Lubomír Voleman, Andrew J. Perry, Neritza Campo Beltrán, Trevor Lithgow, Jan Tachezy, The Minimal Proteome in the Reduced Mitochondrion of the Parasitic Protist Giardia intestinalis PLoS ONE. ,vol. 6, pp. e17285- 17 ,(2011) , 10.1371/JOURNAL.PONE.0017285
Suresh Mathivanan, Hong Ji, Richard J. Simpson, Exosomes: extracellular organelles important in intercellular communication. Journal of Proteomics. ,vol. 73, pp. 1907- 1920 ,(2010) , 10.1016/J.JPROT.2010.06.006
Xi Wang, Ke Dong, Ping Gao, Min Long, Fang Lin, Yuanyuan Weng, Yongri Ouyang, Jihong Ren, Huizhong Zhang, microRNA-34a Sensitizes Lung Cancer Cell Lines to DDP Treatment Independent of p53 Status Cancer Biotherapy and Radiopharmaceuticals. ,vol. 28, pp. 45- 50 ,(2013) , 10.1089/CBR.2012.1218
Arash Javeri, Massoud Ghaffarpour, Masoumeh Fakhr Taha, Massoud Houshmand, Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis. Medical Oncology. ,vol. 30, pp. 413- 413 ,(2013) , 10.1007/S12032-012-0413-7
Laisheng Li, Xinhua Xie, Jinmei Luo, Min Liu, Shaoyan Xi, Jiaoli Guo, Yanan Kong, Minqing Wu, Jie Gao, Zeming Xie, Jun Tang, Xi Wang, Weidong Wei, Mingtian Yang, Mien-Chie Hung, Xiaoming Xie, Targeted Expression of miR-34a Using the T-VISA System Suppresses Breast Cancer Cell Growth and Invasion Molecular Therapy. ,vol. 20, pp. 2326- 2334 ,(2012) , 10.1038/MT.2012.201
Victor Ambros, The functions of animal microRNAs Nature. ,vol. 431, pp. 350- 355 ,(2004) , 10.1038/NATURE02871
Taha Ghawanmeh, Ulf Thunberg, Juan Castro, Fiona Murray, Nongnit Laytragoon-Lewin, miR-34a expression, cell cycle arrest and cell death of malignant mesothelioma cells upon treatment with radiation, docetaxel or combination treatment. Oncology. ,vol. 81, pp. 330- 335 ,(2011) , 10.1159/000334237
A. Kozomara, S. Griffiths-Jones, miRBase: integrating microRNA annotation and deep-sequencing data Nucleic Acids Research. ,vol. 39, pp. 152- 157 ,(2011) , 10.1093/NAR/GKQ1027
Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel, Most mammalian mRNAs are conserved targets of microRNAs Genome Research. ,vol. 19, pp. 92- 105 ,(2008) , 10.1101/GR.082701.108