miR-34a expression, cell cycle arrest and cell death of malignant mesothelioma cells upon treatment with radiation, docetaxel or combination treatment.
作者： Taha Ghawanmeh , Ulf Thunberg , Juan Castro , Fiona Murray , Nongnit Laytragoon-Lewin
DOI: 10.1159/000334237
关键词:
摘要: Objective: Malignant mesothelioma (MM) is a highly aggressive tumour related to asbestos exposure. Histopathologically, the classified as epithelial, sarcomatoid or biphasic. To date, MM still an incurable disease. Methods: evaluate treatment strategies on cells, effects of radiotherapy, docetaxel combination both cells derived from type ZL34 and epithelial M28K were investigated. The TP53 gene, micro-RNA expression, cell cycle distribution death assessed indicators effects. Results: Despite normal gene sequences in these lines, radiation-induced miR-34a expression was detected only cells. Increasing G0/G1 numbers irradiated There more compared highest degree arrest at G2 types obtained presence docetaxel. radiation did not show any additive either Conclusion: Microtubule formation other functions by might be most suitable modulation MM.
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Giovanni Luca Ceresoli, Laura Deborah Locati, Andrés José Marı́a Ferreri, Cesare Cozzarini, Paolo Passoni, Giulio Melloni, Piero Zannini, Angelo Bolognesi, Eugenio Villa, None, Therapeutic outcome according to histologic subtype in 121 patients with malignant pleural mesothelioma Lung Cancer. ,vol. 34, pp. 279- 287 ,(2001) , 10.1016/S0169-5002(01)00257-4
T Soussi, p53 alterations in human cancer: more questions than answers Oncogene. ,vol. 26, pp. 2145- 2156 ,(2007) , 10.1038/SJ.ONC.1210280
Thilo Papp, Holger Schipper, Heidi Pemsel, Ralf Bastrop, Klaus-Michael Muller, Thorsten Wiethege, Dieter Weiss, Elke Dopp, Dietmar Schiffmann, Qamar Rahman, Mutational analysis of N-ras, p53, p16INK4a, p14ARF and CDK4 genes in primary human malignant mesotheliomas International Journal of Oncology. ,vol. 18, pp. 425- 433 ,(2001) , 10.3892/IJO.18.2.425
Yael Aylon, Moshe Oren, Living with p53, dying of p53. Cell. ,vol. 130, pp. 597- 600 ,(2007) , 10.1016/J.CELL.2007.08.005
Zhiwen Liu, Julius Klominek, Inhibition of Proliferation, Migration, and Matrix Metalloprotease Production in Malignant Mesothelioma Cells by Tyrosine Kinase Inhibitors Neoplasia. ,vol. 6, pp. 705- 712 ,(2004) , 10.1593/NEO.04271
Hiroshi I. Suzuki, Kaoru Yamagata, Koichi Sugimoto, Takashi Iwamoto, Shigeaki Kato, Kohei Miyazono, Modulation of microRNA processing by p53 Nature. ,vol. 460, pp. 529- 533 ,(2009) , 10.1038/NATURE08199
Wenwei Hu, Zhaohui Feng, Angelika K. Teresky, Arnold J. Levine, p53 regulates maternal reproduction through LIF Nature. ,vol. 450, pp. 721- 724 ,(2007) , 10.1038/NATURE05993
Gavin J. Gordon, Graham N. Rockwell, Paul A. Godfrey, Roderick V. Jensen, Jonathan N. Glickman, Beow Y. Yeap, William G. Richards, David J. Sugarbaker, Raphael Bueno, Validation of Genomics-Based Prognostic Tests in Malignant Pleural Mesothelioma Clinical Cancer Research. ,vol. 11, pp. 4406- 4414 ,(2005) , 10.1158/1078-0432.CCR-04-2181
Yiwei Li, Xingli Li, Maha Hussain, Fazlul H. Sarkar, Regulation of microtubule, apoptosis, and cell cycle-related genes by taxotere in prostate cancer cells analyzed by microarray. Neoplasia. ,vol. 6, pp. 158- 167 ,(2004) , 10.1593/NEO.03391
Tsung-Cheng Chang, Erik A. Wentzel, Oliver A. Kent, Kalyani Ramachandran, Michael Mullendore, Kwang Hyuck Lee, Georg Feldmann, Munekazu Yamakuchi, Marcella Ferlito, Charles J. Lowenstein, Dan E. Arking, Michael A. Beer, Anirban Maitra, Joshua T. Mendell, Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis Molecular Cell. ,vol. 26, pp. 745- 752 ,(2007) , 10.1016/J.MOLCEL.2007.05.010