p53 regulates maternal reproduction through LIF

摘要: The transcription factor p53 has been studied extensively as a tumour suppressor, but little is known about its normal physiological role. A study in mice now links function to reproduction and fertility. deficiency results poor implantation of embryos female mice, low pregnancy rates small litter sizes. In this role acts by regulating LIF (leukaemia inhibitory factor), cytokine involved blastocyst implantation. This work raises the possibility that important for success particularly women undergoing vitro fertilization or embryo transfer, suggests potential strategy improve efficiency with recurrent failure. gene prevention function. crucial fecundity reported. Extensive studies have shown prevention1. However, Here we show reproduction, gender-specific manner. Significant decreases embryonic implantation, rate size were observed matings p53-/- not male mice. encoding leukaemia (LIF), critical implantation2, was identified p53-regulated functions downstream mediator effect. can regulate both basal inducible LIF. Loss decreased level uteri. Lower levels uteri than those p53+/+ at day 4 pregnancy, when transiently induced high observation probably accounts impaired Administration pregnant restored maternal improving These demonstrate through regulation Evidence accumulating may similar humans.