The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions
作者： Zhaohui Feng , Arnold J. Levine
DOI: 10.1007/978-1-60327-271-1_2
关键词:
摘要: The tumor suppressor p53 plays an important role in maintaining genomic stability and prevention by responding to a wide variety of stress signals initiating transcriptional program produce several different cellular responses. These all interfere with the homeostatic mechanisms that monitor control fidelity DNA replication, chromosome segregation, cell division. IGF-1 mTOR pathways regulate growth division coordinate it nutrient availability energy demands during both development throughout life span organism. To protect cells from errors introduced into such signals, negatively regulates IGF-1/mTOR pathways. In this chapter regulation between are presented. impact pathway upon glycolysis oxidative phosphorylation, ribosomal mitochondrial biogenesis, autophagy explored.
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