Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.

摘要: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues the extremities. It can be rare hereditary disease (pachydermoperiostosis) or secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation HOA. A 77-year-old man presented with fever, diarrhea, oligoarthritis involving left knee ankles. Since synovial fluid aspiration revealed aseptic synovitis Clostridium Difficile toxin was detectable in stool samples, reactive arthritis induced colitis initially suspected. However, presence worsened digital clubbing lack good response steroid therapy led us perform radionuclide bone scanning, which This turned out associated lepidic predominant adenocarcinoma, clinically radiologically difficult distinguish from relapse pneumonia. Consistent literature, HOA tends have variable presentation, mimicking that rheumatic diseases. case shows present as presumptive acute arthritis, it highlights importance patient’s follow-up differential diagnosis inflammatory especially when present.