Life course analysis of the impact of mammary cancer and pyometra on age-anchored life expectancy in female Rottweilers: Implications for envisioning ovary conservation as a strategy to promote healthy longevity in pet dogs.

摘要: Mammary cancer and pyometra are important health hazards associated with ovary conservation in pet dogs. Early ovariohysterectomy may reduce the incidence of these two diseases, but an estimate extent to which development mammary or adversely influences overall longevity is missing. As a first step toward addressing this knowledge gap, results historical cohort study Rottweilers that lived North America reported. Questionnaires completed by owners veterinarians were used obtain lifetime medical information on 242 female Rottweilers, including years exposure, age at death, cause death. To determine was shortened females developed ovary-associated age-anchored life expectancy-defined as median number remaining until death for alive specified ages during course-and lost, measure premature mortality, estimated. carcinoma diagnosed 19 (7.9%) females; diagnosis 8.5 years; case fatality 37%. Pyometra 16 (6.6%) 5.4 7%. Median exposure population 4.3 years. Although risk developing both diseases increased longer (≥4.3 years) also advantage-a 33% decrease living 17 months than shorter (P=0.002). Analysis expectancy showed no time points course current future survival compared who never conditions. This lack disadvantage expected result late-onset, moderate (<50%) (mammary carcinoma) low (<10%) (pyometra). These findings fail support notion strategy, such elective ovariohysterectomy, implemented will beneficially impact longevity. It follows efforts find implement effective longevity-promoting interventions should look beyond reducing particular disease considering trade-offs.