The Golden Retriever Lifetime Study: establishing an observational cohort study with translational relevance for human health.
作者： Michael K. Guy , Rodney L. Page , Wayne A. Jensen , Patricia N. Olson , J. David Haworth
关键词:
摘要: The Golden Retriever Lifetime Study (GRLS) is the first prospective longitudinal study attempted in veterinary medicine to identify major dietary, genetic and environmental risk factors for cancer other important diseases dogs. GRLS an observational that will follow a cohort of 3000 purebred Retrievers throughout their lives via annual online questionnaires from dog owner physical examinations collection biological samples by primary care veterinarian. field comparative investigating naturally occurring disorders pets specifically relevant many have basis disease both animals humans, including cancer, blindness, metabolic behavioural some neurodegenerative disorders. opportunity provide high-quality data translational medical initiatives several categories great. In particular, develop lifetime dataset lifestyle activity, exposure diet history combined with simultaneous sample sets detailed health outcomes incidence this geographically dispersed dogs associations wide variety potential factors. historical context, repeated necessary interrogate complex between genes influences cancer.
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