Subclasses of external adenosine receptors

摘要: Abstract Cell surface adenosine receptors mediate either stimulation or inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], and the that these different responses can be discriminated with selected analogs. 5'-N-Ethylcarboxamide-adenosine is a more potent agonist at stimulatory (Ra) than N6-phenylisopropyladenosine, whereas reverse potency order seen inhibitory (Ri). The intermediate between potencies two relative receptor agonists are maintained in physiological intact cells, such as steroidogenesis lipolysis. As adrenergic receptors, subclasses differ functionally pharmacologically.