Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions.
作者： Ronald T. Coutts , Ping Su , Glen B. Baker
DOI: 10.1016/1056-8719(94)90001-9
关键词: Biology 、 Biochemistry 、 CYP2D6 、 CYP3A 、 Isozyme 、 Cytochrome 、 Amine gas treating 、 CYP3A4 、 Biotransformation 、 Subfamily
摘要: Abstract Metabolic N-dealkylation is a commonly observed biotransformation with tertiary and secondary amine drugs related N-alkylated amides, but surprisingly little known about the cytochrome P-450 isozymes involved in these dealkylation reactions. In this review, evidence provided that supports involvement of various isozymes, especially CYP3A4 other CYP3A subfamily. Although CYP2D6 generally not considered to be capable catalyzing basic drugs, some examples important isozyme reactions are identified. Procedures used identify individual discussed.
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