Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells.

作者: Sebastian Jessberger , Benedikt Römer , Harish Babu , Gerd Kempermann

DOI: 10.1016/J.EXPNEUROL.2005.08.010

关键词: Granule cellNeurogenesisDentate gyrusBiologyProgenitor cellDoublecortinGranule cell dispersionPrecursor cellHippocampal formationNeuroscience

摘要: One neuropathological hallmark of temporal lobe epilepsy is granule cell dispersion, a widening the hippocampal layer (GCL) with abnormally positioned excitatory neurons. The finding that seizure activity also induces adult neurogenesis was taken largely as indicative regenerative attempt, not part pathology. aim our study to characterize potential relationship between dispersion and seizure-induced neurogenesis. Kainic acid (KA)-induced seizures in mice led increased proliferation new neurons persisted for months after seizures. We show proliferative stimulus did affect nestin-expressing early precursor cells primarily respond physiologic mitogenic stimuli, but stimulated division late type-3 progenitor cells, which express doublecortin (DCX), protein associated migration. This delayed presumably interfered migration, leading significant DCX-positive progenitors postmitotic within dentate gyrus layer. propose initial induce ectopic resulting immature Thus, seizure-generated might contribute disease process epilepsy.

参考文章(50)
J. Lauterborn, P. Isackson, M. Bundman, Karl D Murray, C. Gall, Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain. Epilepsy research. Supplement. ,vol. 4, pp. 225- 245 ,(1991)
C. Helmstaedter, Effects of chronic epilepsy on declarative memory systems. Progress in Brain Research. ,vol. 135, pp. 439- 453 ,(2002) , 10.1016/S0079-6123(02)35041-6
Jack M. Parent, Daniel H. Lowenstein, Seizure-induced neurogenesis: are more new neurons good for an adult brain? Progress in Brain Research. ,vol. 135, pp. 121- 131 ,(2002) , 10.1016/S0079-6123(02)35012-X
H. J. Wenzel, C. A. Robbins, L.-H. Tsai, P. A. Schwartzkroin, Abnormal Morphological and Functional Organization of the Hippocampus in a p35 Mutant Model of Cortical Dysplasia Associated with Spontaneous Seizures The Journal of Neuroscience. ,vol. 21, pp. 983- 998 ,(2001) , 10.1523/JNEUROSCI.21-03-00983.2001
Henriette Van Praag, Alejandro F Schinder, Brian R Christie, Nicolas Toni, Theo D Palmer, Fred H Gage, None, Functional neurogenesis in the adult hippocampus Nature. ,vol. 415, pp. 1030- 1034 ,(2002) , 10.1038/4151030A
Gerd Kempermann, Sebastian Jessberger, Barbara Steiner, Golo Kronenberg, Milestones of neuronal development in the adult hippocampus Trends in Neurosciences. ,vol. 27, pp. 447- 452 ,(2004) , 10.1016/J.TINS.2004.05.013
Moritz D Brandt, Sebastian Jessberger, Barbara Steiner, Golo Kronenberg, Katja Reuter, Anika Bick-Sander, Wolfger von der Behrens, Gerd Kempermann, Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice. Molecular and Cellular Neuroscience. ,vol. 24, pp. 603- 613 ,(2003) , 10.1016/S1044-7431(03)00207-0
Teruyuki Tanaka, Finley F. Serneo, Huang-Chun Tseng, Ashok B. Kulkarni, Li-Huei Tsai, Joseph G. Gleeson, Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron. ,vol. 41, pp. 215- 227 ,(2004) , 10.1016/S0896-6273(03)00852-3