作者: Sebastian Jessberger , Benedikt Römer , Harish Babu , Gerd Kempermann
DOI: 10.1016/J.EXPNEUROL.2005.08.010
关键词: Granule cell 、 Neurogenesis 、 Dentate gyrus 、 Biology 、 Progenitor cell 、 Doublecortin 、 Granule cell dispersion 、 Precursor cell 、 Hippocampal formation 、 Neuroscience
摘要: One neuropathological hallmark of temporal lobe epilepsy is granule cell dispersion, a widening the hippocampal layer (GCL) with abnormally positioned excitatory neurons. The finding that seizure activity also induces adult neurogenesis was taken largely as indicative regenerative attempt, not part pathology. aim our study to characterize potential relationship between dispersion and seizure-induced neurogenesis. Kainic acid (KA)-induced seizures in mice led increased proliferation new neurons persisted for months after seizures. We show proliferative stimulus did affect nestin-expressing early precursor cells primarily respond physiologic mitogenic stimuli, but stimulated division late type-3 progenitor cells, which express doublecortin (DCX), protein associated migration. This delayed presumably interfered migration, leading significant DCX-positive progenitors postmitotic within dentate gyrus layer. propose initial induce ectopic resulting immature Thus, seizure-generated might contribute disease process epilepsy.