Cyclins and related kinases in cancer cells

摘要: Tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key cycle molecules that regulate the activity of cyclin-dependent kinases (CDKs). These protein control progression through different phases division cycle. Tumor-associated their activating partners, cyclins, CDK inhibitors help to sustain independence from external mitogenic anti-mitogenic signals. The significant frequency these human cancer and recent studies genetically-engineered mouse models predict inhibition CDKs might have therapeutic value. Most interphase are dispensable for development but may prevent DNA replication some specific tumor cells. On other hand, inactivation mitotic efficiently prevents throughout combination biochemical data on function regulators will be instrumental define new targeted therapies inhibiting