New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers

摘要: Breast cancer is the most frequent female malignancy worldwide. Current strategies in breast therapy, including classical chemotherapy, hormone and targeted therapies, are usually associated with chemoresistance serious adverse effects. Advances our understanding of changes affecting interactome advanced chemoresistant tumors have provided novel therapeutic targets, including, cyclin dependent kinases, mammalian target rapamycin, Notch, Wnt Shh. Inhibitors these molecules recently entered clinical trials mono- combination therapy metastatic chemo-resistant cancers. Anticancer epigenetic drugs, mainly histone deacetylase inhibitors DNA methyltransferase inhibitors, also trials. Because complexity heterogeneity cancer, future lies application individualized tailored regimens. Emerging targets implications for personalized-based development herein discussed.