Evaluation of the safety of ancient strains of wheat in coeliac disease reveals heterogeneous small intestinal T cell responses suggestive of coeliac toxicity.
作者： Tanja Šuligoj , Armando Gregorini , Mariastella Colomba , H. Julia Ellis , Paul J. Ciclitira
DOI: 10.1016/J.CLNU.2013.02.003
关键词: Gluten 、 Coeliac disease 、 Enteropathy 、 Genome 、 Tissue transglutaminase 、 Toxicity 、 Immunogenicity 、 Ploidy 、 Genetics 、 Biology
摘要: summary Background & aims: Coeliac disease is a chronic small intestinal immune-mediated enteropathy triggered by dietary gluten in genetically predisposed individuals. Since it unknown if all wheat varieties are equally toxic to coeliac patients seven Triticum accessions showing different origin (ancient/modern) and ploidy (di-, tetra- hexaploid) were studied. Materials methods: Selected strains of ancient monococcum precoce (AA genome) speltoides (BB genome), turgidum durum (AABB including two (Graziella Ra Kamut) modern (Senatore Cappelli Svevo) aestivum compactum (AABBDD genome). Small gluten-specific T-cell lines generated from 13 tested with proliferation assays. Results: All independent or ancient/modern heterogeneous responses covering wide ranges stimulation indices. Conclusion: Ancient wheat, although previously suggested be low devoid toxicity, should for immunogenicity using multiple rather than clones assess their potential toxicity. Our findings provide further evidence the need strict gluten-free diet patients, avoidance wheat.
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