Animal models for ebolavirus countermeasures discovery: what defines a useful model?

摘要: Introduction: Ebolaviruses are highly pathogenic filoviruses, which cause disease in humans and nonhuman primates (NHP) Africa. The Zaire ebolavirus outbreak 2014, continues to greatly affect Western Africa other countries the hemorrhagic fever was exported due travel of unsymptomatic yet infected individuals, complicated by lack available licensed vaccines or therapeutics combat infection. After almost a year research at an increased pace find test therapeutics, there is now deeper understanding models for Demonstration vaccine therapeutic efficacy NHP infection crucial development eventual licensure medical countermeasures, so that safe effective countermeasures can be accelerated into human clinical trials.Areas covered: authors describe (EHF) various animal species: mice, guinea pigs, ...