Clinical Significance of Serum Bilirubins: Recent Advances

作者: Maurizio Muraca , Rocco Orlando , Mario Strazzabosco , Gino Nassuato , Flavio Lirussi

DOI: 10.1007/978-3-642-72631-6_22

关键词: Unconjugated bilirubinClinical valueSerum bilirubinClinical significancePharmacologyBilirubinHepatobiliary diseaseChemistryDimethyl esterConjugated bilirubin

摘要: The potential clinical value of serum bilirubin cannot be fully exploited because analytical problems affecting in particular the determination conjugated pigment fraction. In this review, some recent methodological advances are described which now allow direct quantitation unconjugated bilirubin, monoconjugate, and diconjugate human serum. This novel methodology has greatly improved our understanding mechanisms determining levels serum, changes occurring pathological conditions.

参考文章(14)
Rudi Schmid, The identification of direct-reacting bilirubin as bilirubin glucuronide. Journal of Biological Chemistry. ,vol. 229, pp. 881- 888 ,(1957) , 10.1016/S0021-9258(19)63692-6
F. P. Van Roy, K. P. M. Heirwegh, Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor Biochemical Journal. ,vol. 107, pp. 507- 518 ,(1968) , 10.1042/BJ1070507
Frans Compernolle, Gustaaf P. Van Hees, Norbert Blanckaert, Karel P. M. Heirwegh, Glucuronic acid conjugates of bilirubin-IXα in normal bile compared with post-obstructive bile. Transformation of the 1-O-acylglucuronide into 2-, 3-, and 4-O-acylglucuronides Biochemical Journal. ,vol. 171, pp. 185- 201 ,(1978) , 10.1042/BJ1710185
N Blanckaert, F Compernolle, P Leroy, R Van Houtte, J Fevery, K P M Heirwegh, The fate of bilirubin-IXα glucuronide in cholestasis and during storage in vitro. Intramolecular rearrangement to positional isomers of glucuronic acid Biochemical Journal. ,vol. 171, pp. 203- 214 ,(1978) , 10.1042/BJ1710203
J. P. Kennedy, Bile pigments : chemical, biological and clinical aspects Academic Press. ,(1968)
B F Scharschmidt, N Blanckaert, F A Farina, P M Kabra, B E Stafford, R A Weisiger, Measurement of serum bilirubin and its mono- and diconjugates: application to patients with hepatobiliary disease. Gut. ,vol. 23, pp. 643- 649 ,(1982) , 10.1136/GUT.23.8.643
J. Fevery, B. Van Damme, R. Michiels, J. De Groote, K. P. M. Heirwegh, Bilirubin conjugates in bile of man and rat in the normal state and in liver disease Journal of Clinical Investigation. ,vol. 51, pp. 2482- 2492 ,(1972) , 10.1172/JCI107062