The Biologic Principles of Poliovirus Eradication

摘要: The biologic principles for the global eradication of poliomyelitis are as follows: Poliovirus causes acute, nonpersistent infections, virus is transmitted by infectious humans or their waste, survival in environment finite, only reservoir, and immunization with polio vaccine interrupts transmission. These appear to be sound. potential prolonged excretion immunocompromised patients requires further definition, although there no epidemiologic evidence a threat eradication. Survival poliovirus highly variable, but viral inactivation usually complete within months. Higher primates may infected poliovirus, they unlikely reservoirs nature. reservoir remaining after will laboratory stocks. Serious attention must given reducing this source infection. Polio through evidenced documented absence an increasing number countries progressive disappearance genotypes.