Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.
作者： S A Kharitonov , B J O'Connor , D J Evans , P J Barnes
DOI: 10.1164/AJRCCM.151.6.7767537
关键词: Methacholine 、 Allergen 、 Allergy 、 Exhaled nitric oxide 、 Immunology 、 Asthma 、 Inflammation 、 Nitric oxide 、 Respiratory disease 、 Medicine
摘要: The concentration of nitric oxide (NO) is increased in the exhaled air asthmatic patients and may reflect cytokine-mediated inflammation airways. We investigated whether allergen-induced causes an elevation level NO. Of 25 who underwent allergen challenge, 16 developed dual early late responses, whereas eight had a single response. In with response, maximal fall FEV1 during response was 26.8 +/- 4.2% at 9 h there significant increase NO (maximal 59.4 9.8%) 10 after challenge. There relationship between size (r = 0.75, p < 0.01). have no NO, exception time point 21 h. five given control challenge methacholine change increase...
sci-hub.se 参考文章(29)
Y Yui, R Hattori, K Kosuga, H Eizawa, K Hiki, S Ohkawa, K Ohnishi, S Terao, C Kawai, Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils. Journal of Biological Chemistry. ,vol. 266, pp. 3369- 3371 ,(1991) , 10.1016/S0021-9258(19)67800-2
Michael J. Campbell, T. D. V. Swinscow, Statistics at Square One ,(1976)
E.J.M. Weersink, D.S. Postma, R. Aalbers, J.G.R. de Monchy, Early and late asthmatic reaction after allergen challenge Respiratory Medicine. ,vol. 88, pp. 103- 114 ,(1994) , 10.1016/0954-6111(94)90021-3
P. H. Howarth, P. Bradding, S. Montefort, D. Peroni, R. Djukanovic, M. P. Carroll, S. T. Holgate, Mucosal Inflammation and Asthma American Journal of Respiratory and Critical Care Medicine. ,vol. 150, pp. 18- 22 ,(1994) , 10.1164/AJRCCM/150.5_PT_2.S18
K. ALVING, C. FORNHEM, E. WEITZBERG, J. M. LUNDBERG, Nitric oxide mediates cigarette smoke‐induced vasodilatory responses in the lung Acta Physiologica Scandinavica. ,vol. 146, pp. 407- 408 ,(1992) , 10.1111/J.1748-1716.1992.TB09439.X
S.A. Kharitonov, D. Yates, R.A. Robbins, P.J. Barnes, R. Logan-Sinclair, E.A. Shinebourne, Increased nitric oxide in exhaled air of asthmatic patients The Lancet. ,vol. 343, pp. 133- 135 ,(1994) , 10.1016/S0140-6736(94)90931-8
Q Hamid, DR. Springall, JM Polak, V Riveros-Moreno, P Chanez, J Bousquet, Philippe Godard, S Holgate, P Howarth, A Redington, Induction of nitric oxide synthase in asthma The Lancet. ,vol. 342, pp. 1510- 1513 ,(1993) , 10.1016/S0140-6736(05)80083-2
P. J. BARNES, Frontiers in medicine: New aspects of asthma Journal of Internal Medicine. ,vol. 231, pp. 453- 461 ,(1992) , 10.1111/J.1365-2796.1992.TB00960.X
L. Kobzik, D. S. Bredt, C. J. Lowenstein, J. Drazen, B. Gaston, D. Sugarbaker, J. S. Stamler, Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization American Journal of Respiratory Cell and Molecular Biology. ,vol. 9, pp. 371- 377 ,(1993) , 10.1165/AJRCMB/9.4.371
M. S. Mulligan, J. M. Hevel, M. A. Marletta, P. A. Ward, Tissue injury caused by deposition of immune complexes is L-arginine dependent Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 6338- 6342 ,(1991) , 10.1073/PNAS.88.14.6338