Linac-based stereotactic body radiation therapy for treatment of glomus jugulare tumors.

摘要: Abstract Background: Glomus jugulare tumors are rare, typically benign, that arise from the neural crest cells associated with autonomic ganglia in and around jugular bulb. Treatment options for glomus include embolization followed by resection, fractionated external beam radiation therapy (EBRT), stereotactic radiosurgery (SRS), and/or body (SBRT). Materials methods: 18 patients were treated linear-accelerator based (SBRT) between May 2002 November 2008. Fifteen (83%) had single 3 bilateral (although each of these a tumor targeted). The median volume was 5.83cm (range, 0.32–35.47cm ). Ten (56%) previously untreated, 8 (44%) persistent after previous surgical resection. One patient undergone EBRT 2 Gamma Knife to intracranial portion their tumor, planned SBRT extracranial 2–4months later at our institution. prescribed dose 20Gy fractions (range: 16–25Gy 1–5 fx) 80% isodose line. prescription coverage 93.6% 83–98.72%). Results: Median follow-up entire cohort 22months. All alive time last imaging available review. stable 17 decreased size one – yielding local control rate 100%. No experienced any new or worsening treatment-related neurologic deficits. Conclusions: is safe efficacious treatment modality tumors.