Effect of exogenous angiotensin II on renal hemodynamics in the awake rat. Measurement of afferent arteriolar diameter by the microsphere method.
作者： C H Hsu , T W Kurtz , J M Slavicek
关键词: Internal medicine 、 Inulin Clearance 、 Angiotensin II 、 Filtration fraction 、 Mean arterial pressure 、 Vascular resistance 、 Endocrinology 、 Renal blood flow 、 Afferent arterioles 、 Cardiac output 、 Chemistry
摘要: We measured cardiac output (CO), renal blood flow (RBF), plasma (RPF), and afferent arteriolar diameter by the microsphere method, inulin clearance (GFR) simultaneously in awake rats given an infusion of exogenous angiotensin II (100 ng/min per kg). Angiotensin did not affect CO, whereas both RBF RPF decreased significantly infused with (RBF, 2.88 +/- 0.11, mean SE; RPF, 1.78 0.09, n = 6) when compared to control animals saline 4.58 0.31; 2.80 0.24 ml/min 100 g, 6, P less than 0.005, respectively). Both arterial pressure (MAP) vascular resistance (RVR) were higher antiogensin controls. The decrease GFR parallel reduction as reflected their values filtration fraction (41.1 1.6%, that controls (33.7 2.4%, 0.05). Despite significant elevations MAP RVR II, (19.6 micron) was different from (20.1 0.39 micron). conclude preferentially acts at site postglomerular vasculature but arteriole.
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