The Effects of Glial Cell Line-Derived Neurotrophic Factor after Spinal Cord Injury
作者： Konstantin Rosich , Bishoy F. Hanna , Rami K. Ibrahim , Daniel J. Hellenbrand , Amgad Hanna
关键词: Glial cell line-derived neurotrophic factor 、 Peripheral nervous system 、 Neurotrophic factors 、 Central nervous system 、 Allodynia 、 Neuroscience 、 Neurotrophin 、 Medicine 、 Autonomic nervous system 、 Spinal cord injury
摘要: Abstract Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United States. The use of growth factors potential treatment for reducing secondary damage, promoting axon growth, and restoring some lost function post-SCI. Glial cell line-derived neurotrophic factor (GDNF) an important factor, because it can affect both neurons support cells. Here, we give in-depth review previously published literature where GDNF was used to treat SCI. effects have been shown decrease lesion size, improve allodynia, regenerate axons central nervous system peripheral system. necessary early development, lack lead abnormal development autonomic or death. Exogenous administration either before immediately after SCI most effective. Even though be directly administered, genetically modified cells are often as delivery vehicle. Several different...
sci-hub.se 参考文章(199)
Hari S. Sharma, L. Wiklund, R. D. Badgaiyan, S. Mohanty, P. Alm, Intracerebral administration of neuronal nitric oxide synthase antiserum attenuates traumatic brain injury-induced blood-brain barrier permeability, brain edema formation, and sensory motor disturbances in the rat Acta Neurochirurgica. ,vol. 96, pp. 288- 294 ,(2006) , 10.1007/3-211-30714-1_62
H. S. Sharma, F. Nyberg, T. Gordh, P. Alm, Topical application of dynorphin A (1-17) antibodies attenuates neuronal nitric oxide synthase up-regulation, edema formation, and cell injury following focal trauma to the rat spinal cord Acta Neurochirurgica. ,vol. 96, pp. 309- 315 ,(2006) , 10.1007/3-211-30714-1_66
HARI SHANKER SHARMA, Pathophysiology of the Blood–Spinal Cord Barrier in Traumatic Injury Blood-Spinal Cord and Brain Barriers in Health and Disease. pp. 437- 518 ,(2004) , 10.1016/B978-012639011-7/50027-9
Trevor Owens, Hartmut Wekerle, Jack Antel, Genetic models for CNS inflammation Nature Medicine. ,vol. 7, pp. 161- 166 ,(2001) , 10.1038/84603
Matt S. Ramer, John V. Priestley, Stephen B. McMahon, Functional regeneration of sensory axons into the adult spinal cord Nature. ,vol. 403, pp. 312- 316 ,(2000) , 10.1038/35002084
William T.J. Hendriks, Marc J. Ruitenberg, Bas Blits, Gerard J. Boer, Joost Verhaagen, Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. Progress in Brain Research. ,vol. 146, pp. 451- 476 ,(2004) , 10.1016/S0079-6123(03)46029-9
M. Birdsall Abrams, Anna Josephson, Cecilia Dominguez, Johanna Öberg, Margarita Diez, Christian Spenger, Lars Olson, Fredrik Piehl, Olle Lidman, Recovery from spinal cord injury differs between rat strains in a major histocompatibility complex-independent manner European Journal of Neuroscience. ,vol. 26, pp. 1118- 1127 ,(2007) , 10.1111/J.1460-9568.2007.05725.X
Orly Lazarov‐Spiegler, Arieh S. Solomon, Adi Ben Zeev‐Brann, David L. Hirschberg, Vered Lavie, Michal Schwartz, Transplantation of activated macrophages overcomes central nervous system regrowth failure. The FASEB Journal. ,vol. 10, pp. 1296- 1302 ,(1996) , 10.1096/FASEBJ.10.11.8836043
Fausto Pierdoná Guzen, Ricardo José de Almeida Leme, Michele Schultz Ramos de Andrade, Bianca Aparecida de Luca and, Gerson Chadi, Glial cell line-derived neurotrophic factor added to a sciatic nerve fragment grafted in a spinal cord gap ameliorates motor impairments in rats and increases local axonal growth Restorative Neurology and Neuroscience. ,vol. 27, pp. 1- 16 ,(2009) , 10.3233/RNN-2009-0454
Yves Sagot, Thierry Rossé, Richard Vejsada, Daniel Perrelet, Ann C. Kato, Differential effects of neurotrophic factors on motoneuron retrograde labeling in a murine model of motoneuron disease. The Journal of Neuroscience. ,vol. 18, pp. 1132- 1141 ,(1998) , 10.1523/JNEUROSCI.18-03-01132.1998