Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig
作者： E.A Campbell , C.T Gentry , S Patel , M.S Panesar , C.S.J Walpole
DOI: 10.1016/S0306-4522(98)00318-2
关键词: Anesthesia 、 Neuralgia 、 Antagonist 、 Hyperalgesia 、 Guinea pig 、 Pharmacology 、 Receptor 、 Peripheral neuropathy 、 Analgesic 、 Medicine 、 Neuropathic pain
摘要: Neuropathic pain is poorly managed by conventional analgesic therapy, such as non-steroidal anti-inflammatory drugs and opiates. The development of animal models peripheral neural damage has aided in our understanding the pathology pharmacology neuropathic pain. This report first clear demonstration using selective neurokinin-1 receptor antagonists a potentially novel therapeutic approach to treatment resulting from nerve guinea-pig model. antagonists, SDZ NKT 343 LY 303,870 significantly reduced mechanical hyperalgesia following oral intrathecal administration. (R,R)-SDZ NK T343, enantiomer did not show anti-hyperalgesic activity. RPR 100,893 showed significant activity only administration suggesting poor absorption or low level penetration blood-brain barrier. These results imply that offer new class with largely central site action
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