Experimental peripheral neuropathy decreases the dose of substance P required to increase excitatory amino acid release in the CSF of the rat spinal cord.
作者： Stephen R. Skilling , Donald H. Harkness , Alice A. Larson
DOI: 10.1016/0304-3940(92)90865-5
关键词: Anesthesia 、 Microdialysis 、 Hyperalgesia 、 Sciatic nerve 、 Nociception 、 Spinal cord 、 Glutamate receptor 、 Substance P 、 Nerve injury 、 Internal medicine 、 Endocrinology 、 Medicine
摘要: Partial ligation of the sciatic nerve rats produces hyperalgesia similar to that seen in humans following injury. In this study, we used microdialysis spinal cord cerebral fluid (CSF) test hypothesis is due an enhanced release excitatory amino acids (EAA) response substance P (SP). Intrathecal SP caused aspartate and glutamate CSF with partial at a dose did not cause sham operated animals. Neonatal capsaicin pretreatment blocked SP-induced EAA both ligated Release EAAs animals was significantly different from sham-operated higher doses or chemical nociceptive stimulation. These results demonstrate ligation-induced decrease required initiate cord, change which could play important role hyperalgesia.
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