The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor-related survival in neoadjuvant treated locally advanced gastric cancer.
作者： Katja Ott , Holger Vogelsang , Noemi Marton , Karen Becker , Florian Lordick
DOI: 10.1002/IJC.22235
关键词: Methylenetetrahydrofolate reductase 、 Genotyping 、 Stomach cancer 、 Genotype 、 Biology 、 Tandem repeat 、 Cancer 、 Thymidylate synthase 、 Pathology 、 Cancer research 、 Fluorouracil
摘要: We evaluated DNA polymorphisms in the thymidylate synthase (TS) and 5,10-methylene-tetrahydrofolate reductase (MTHFR) genes for an association with response survival locally advanced gastric cancer treated 5-FU based preoperative chemotherapy (CTx). of 238 patients (CTx-group: total n 5 135, completely resected (R0) 102; without CTx: R0 103) was isolated from blood or nontumorous tissues. In CTx-group, genotyping tandem repeat G/C polymorphism triple promoter region TS gene C677T MTHFR performed. None genotypes were associated histopathological only significantly related to (all p 0.002; 102, 0.007; log-rank test). Multivariate analysis revealed ypN (p C second 3R allele has been demonstrated alter tran
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