Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase
作者： Nobuyuki Horie , Hideo Aiba , Katsuhiko Oguro , Hiroatsu Hojo , Keiichi Takeishi
DOI: 10.1247/CSF.20.191
关键词:
摘要: Triple tandemly repeated sequences and the corresponding complementary sequence are known to exist in 5'-terminal regulatory region of human gene for thymidylate synthase (TS). To examine function these sequences, a set deletion mutants was prepared used transient expression assay. The results showed that at least one its were necessary efficient gene. As another approach understanding this unique structure, DNA polymorphism same analyzed. In addition TS with triple tandem repeat, double repeat found genomes normal subjects an estimated frequency 19% when 21 unrelated Japanese activity reporter linked promoter genes two types examined result lower than Thus, it appears polymorphic contribute efficiency
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