The role of methionine in methotrexate-sensitive and methotrexate-resistant mouse leukemia L1210 cells.
作者： Kevin J Scanlon , Mohammed Kashani-Sabet , Arlene R. Cashmore , Michele Pallai , Barbara A. Moroson
DOI: 10.1007/BF00296250
关键词: Biology 、 Cell growth 、 Methionine synthase 、 Methionine transport 、 L1210 cells 、 Methionine 、 Biochemistry 、 Metabolism 、 Amino acid 、 Cell culture
摘要: A mouse L1210 leukemia cell line was made 25-fold resistant to methotrexate (MTX) and had altered methionine transport metabolism. cells also a 50-fold decrease in the exogenous requirement for optimal growth compared parent cells. This change associated with differences metabolism between MTX-sensitive MTX-resistant lines. Analysis of amino acid systems revealed different K1 Vmax properties nonmetabolizable analogues. There greater than twofold initial sodium-dependent uptake Amino competition experiments substrate specificities The cellular alterations occurring upon resistance may result from methotrexatemembrane interactions, have been previously observed cisplatinum-resistant Thus modulation provide biochemical basis MTX cisplatinum collateral resistance.
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