Rheologic predictors of the severity of the painful sickle cell crisis.

作者: SK Ballas , J Larner , ED Smith , S Surrey , E Schwartz

DOI: 10.1182/BLOOD.V72.4.1216.1216

关键词: Alpha-thalassemiaSignificant positive correlationSickle cell anemiaGene numberGastroenterologyPredictive valueMedicineFetal hemoglobinCellInternal medicineImmunologyVascular endothelium

摘要: Deformable sickle erythrocytes have been reported by Mohandas and Evans to be more adherent vascular endothelium than rigid irreversibly sickled cells (ISC). To define the clinical implications of this finding we determined genetic, hematological, clinical, rheological characteristics obtained from 65 patients with cell anemia fetal hemoglobin (Hb F) levels less 15%. The alpha-globin gene number had a significant effect on hematological parameters, percentage dense cells, ISC number, HB A2 levels. presence or absence alpha thalassemia, however, no frequency severity painful crisis (r = 0.06, P greater .05). RBC deformability, an ektacytometer, showed great heterogeneity among three four genes. Linear regression analyses data positive correlation deformability 0.49, .001), negative correlations -0.37, .002), -0.46, .001). We propose that deformable are, their adherence endothelium, they cause vaso-occlusive crises, (or ISC) seem predictive value crises in anemia.

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