Modulation of Erythrocyte-Endothelial Interactions and the Vasocclusive Severity of Sickling Disorders
作者： RP Hebbel , CF Moldow , MH Steinberg
DOI: 10.1182/BLOOD.V58.5.947.947
关键词: Vascular endothelium 、 Clinical severity 、 Hemoglobin 、 Cell adhesion 、 Immunology 、 Medicine 、 Fibrinogen 、 Anemia 、 Endothelium
摘要: The abnormal adherence of sickle erythrocytes to cultured human vascular endothelium varies among patients and correlates with vasocclusive severity within the different sickling disorders. For individual patients, development an acute event is not accompanied by increase in inherent propensity for their adhere endothelium. However, onset vasocclusion appears be associated appearance plasma factors, such as fibrinogen, which enhance In addition, even more avidly injured under hyperosmolar conditions. Thus, overall clinical disorders correlate endothelium, changes red cells' environment may help precipitate crises sudden facilitation erythrocyte/endothelial interactions.
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