Vascular Lesions: Possible Pathogenetic Basis of the Generalized Shwartzman Reaction

摘要: Evidence of vascular injury was found in rabbits after a single small dose endotoxin from Escherichia coli. Eighty percent the treated animals developed circulating endothelial cells, leukopenia, and thrombocytopenia, 50 had aortic lesions as determined by electron microscopy. Prior anticoagulation with heparin did not prevent this response. No control showed these abnormalities.