Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation.

摘要: The mechanism of isolated thrombocytopenia in septicemia is unknown, but compensated disseminated intravascular coagulation (DIC) has been suggested as a possible cause. To investigate this possibility, platelet counts and sensitive assays for vivo thrombin plasmin generation, including fibrinogen gel chromatography fibrinopeptide A (FPA) assays, were obtained on 31 septicemic patients. Fifteen 17 patients with gram-negative 8 14 gram-positive had thrombocytopenia. Platelet survival studied demonstrated decreased survival. In 11 12 severe (platelet count less than 50,000mul), there was laboratory evidence coagulation. contrast, little moderate 50,000 to 150,000/mul) or 7 normal counts. This report indicates that while DIC accompanies many thrombocytopenia, frequently It apparent factors other must play role producing the septicemia.