Identification of Hydroxylated Octa- and Nona-Bromodiphenyl Ethers in Human Serum from Electronic Waste Dismantling Workers

摘要: Previous studies have reported high serum concentrations of polybrominated diphenyl ethers, especially decabromodiphenyl ether (BDE-209), in the residents an electronic waste (e-waste) dismantling site Guiyu town, South China. In present study, human samples this region were collected and pooled for identification hydroxylated ethers (OH-PBDEs). Three OH-PBDEs, including two octabromodiphenyl (OH-octaBDEs, 6-OH-BDE196 6-OH-BDE199) one nonabromodiphenyl (OH-nonaBDE, 6'-OH-BDE206), first structurally identified. Identification was done by coeluting a mixture synthetic authentic standards with methylated OH-PBDEs from using gas chromatography columns different polarities. The results supported full scan mass spectrometric data electron capture negative ionization mode. All three OH-PBDE metabolites had hydroxy groups substituted ortho position. These indicate that higher brominated such as OH-octaBDEs OH-nonaBDEs can accumulate blood. suggest could be oxidatively metabolized into humans. Because low also detected abiotic media, further investigations are needed to determine presence environment region.