Blockade of muscarinic receptors impairs reconsolidation of older fear memory by decreasing cholinergic neurotransmission: A study in rat model of PTSD.
作者： Sahar Rafiq , Zehra Batool , Laraib Liaquat , Saida Haider
DOI: 10.1016/J.LFS.2020.118014
关键词: Atropine 、 Medicine 、 Neuroscience 、 Long-term memory 、 Propranolol 、 Muscarinic acetylcholine receptor 、 Memory consolidation 、 Fear conditioning 、 Acetylcholine 、 Antagonist
摘要: The age and strength of fear memory are two potential parameters that can be influenced by the impairing effects pharmacological agents on reconsolidation memory. In reconsolidation, stored information is rendered labile again after being reactivated. Pharmacological manipulations at this stage result in an inability to retrieve memories, suggesting they erased or persistently inhibited. This impairment phenomenon valuable treat post-traumatic stress disorders (PTSD). Previously β-adrenergic antagonist propranolol has been repeatedly reported impair treatment PTSD. Atropine also shown disrupt formation. present study was therefore designed compare atropine older rat model PTSD using Pavlovian conditioning apparatus. For purpose 18 rats were taken divided into control, groups subjected trials order develop animal To evaluate propranolol, short term long tested reactivation rats. findings demonstrate significantly decreases expression. These results suggest reduces memories may effective psychiatric especially
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