Procoagulant activity expression by macrophages from atheromatous vascular plaques.

摘要: Abstract Embolization of thrombi from ulcerated plaques is an important cause morbidity atherosclerotic carotid artery disease. Factors controlling thrombus formation on these lesions are not well understood. Macrophages were isolated to assess their potential promote local fibrin deposition. Plaques collected 11 patients undergoing endarterectomy and 9 reconstructive procedures for disease distal aorta or femoral arteries. Blood was also concurrently isolate monocytes. Procoagulant activity (PCA) macrophages (8.6 ± 4.1 mU/10 6 cells) significantly higher than that non-carotid (0.35 0.20 cells; P cells (n = 5) compared 2.4 0.8 6) plaque assymptomatic patients. Carotid macrophage PCA factor V VII dependent. Its functional inhibited by anti-tissue antibody, immunohistochemical studies tissue sections showed in areas where abundant. These demonstrate within have augmented procoagulant with blood monocytes other indicate activated. Augmented may contribute plaques.