Antimicrobial Resistance Is a Global Health Emergency

摘要: Leading experts have declared that the end of age antibiotics is imminent and this development could undermine foundation much modern medicine public health.1,2 Since were first introduced into clinical practice some 80 years ago, microbes been evolving ways to resist these drugs, but in recent problem antimicrobial resistance (AMR) has rapidly getting worse.1 It estimated there are at least 2 million cases per year AMR infection United States directly resulting 23,000 deaths.2 In many nations around world, worse than US. For example, rates gram-negative reach over 25% parts southern Europe, all 6 regions World Health Organization (WHO) include countries reporting more a 50% incidence Klebsiella third-generation cephalosporins.3,4 There no reliable estimates number globally, largely because surveillance incomplete; however, fragmentary evidence suggests developing countries.1 These infections occur nearly medical settings. A substantial percentage childhood ear infections, urinary tract community-acquired pneumonias, sexually transmitted wound skin caused by pathogens evolved one or which they previously sensitive. WHO report with penicillin exceeding pneumococcal half wherein rate gonorrhea cephalosporins exceeds 50%.4