Conversion of ecdysone and 20-Hydroxyecdysone into 26-OIC derivatives is a major pathway in larvae and pupae of species from three insect orders
作者： Ren� Lafont , Catherine Blais , Philippe Beydon , Jean-Fran�ois Modde , Ulrike Enderle
关键词: Pieris brassicae 、 Ecdysone 、 Biology 、 Hormone 、 20-Hydroxyecdysone 、 Biochemistry 、 Insect 、 Steroid 、 Chemical structure 、 Metabolism
摘要: Insects convert ecdysone and 20-hydroxyecdysone into their corresponding 26-oic derivatives, named ecdysonoic acid 20-hydroxyecdysonoic respectively. The conversion takes piace in several tissues can either be the only pathway for converting highly polar ecdysteroids, or coexist with various conjugating mechanisms. 20-Hydroxyecdysonoic was isolated from Pieris brassicae pupae as its methyl ester derivative. Its chemical structure identified by Cl/D mass spectrometry compared a synthetic compound (20-hydroxy-25-deoxyecdysonoic acid) chemically prepared oxidation of inokosterone (20,26-dihydroxy-25-deoxyecdysone). Natural acids appear to exist mixture 25R 25S isomers. The significance this is discussed comparison similar reactions occuring metabolism steroid hormones vertebrates.
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