The dexmedetomidine "augmented" sedato analgesic cocktail: An effective approach for sedation in prolonged endoscopic retrograde cholangio-pancreatography

摘要: Background and Aims: In absence of any published standard guideline for sedation or anesthesia practice prolonged therapeutic endoscopic retrograde cholangio-pancreatography (ERCP), safe cost-effective protocol is the need hour. Our study aims to evaluate efficacy a dexmedetomidine as an add-on deep ERCP compare three regimens regarding safety efficacy. Material Methods: Forty-five consecutively enrolled patients planned assumed have procedural duration (>50 min) were divided into groups in randomized assessor blinded fashion. Group 1 received propofol midazolam, 2 sedato-analgesic cocktail containing ketamine-propofol-midazolam-pentazocine, 3 sedate-analgesic plus infusion under monitoring vital parameters according judgment concerned anesthesiologist. Total requirement, episodes gagging, oxygen desaturation, changes mean blood pressure (MBP), recovery satisfaction score endoscopist, anesthetist patient noted analyzed statistically using one way ANOVA with Bonferroni correction Chi-square test. Results: Mean incidences gagging desaturation was significantly less compared 1. MBP more stable faster 3. Anesthetist's even Conclusions: The superior conventional propofol-midazolam regimen, increased cocktail. It reduces helps maintain level increases anesthetist.