Cocktail sedation containing propofol versus conventional sedation for ERCP: a prospective, randomized controlled study

摘要: ERCP practically requires moderate to deep sedation controlled by a combination of benzodiazepine and opiod. Propofol as sole agent may cause oversedation. A (cocktail) infused propofol, meperidine, midazolam can reduce the dosage propofol we hypothesized that it might decrease risk We prospectively compare efficacy, recovery time, patient satisfactory, side effects between cocktail conventional sedations in patients undergoing ERCP. were randomized into 2 groups; group (n = 103) controls (n = 102). For induction, 25 mg meperidine 2.5 mg administered both groups. In group, bolus dose 1 mg/kg was continuously infused. controls, or 2.5 mg/kg titrated maintain level sedation. average administration rate 6.2 mg/kg/hr. control group; weight base 1.03 mg/kg 0.12 mg/kg, respectively. Recovery times patients’ satisfaction scores groups 9.67 minutes 12.89 minutes (P = 0.045), 93.1and 87.6 (P <0.001), Desaturation rates 58.3% 31.4% All desaturations corrected with temporary oxygen supplementation without need for scope removal. Cocktail containing provides faster time better However, mild degree desaturation still develop. ClinicalTrials.gov, NCT01540084