Hydrolytic and microbial degradation of multi-block polyurethanes based on poly(ɛ-caprolactone)/poly(ethylene glycol) segments

作者: S. Cometa , I. Bartolozzi , A. Corti , F. Chiellini , E. De Giglio

DOI: 10.1016/J.POLYMDEGRADSTAB.2010.07.007

关键词: PolycaprolactoneSwellingAmphiphileHydrolysisPEG ratioCopolymerPolymer chemistryMaterials scienceCondensation polymerChemical engineeringBiodegradationMaterials ChemistryMechanics of MaterialsPolymers and PlasticsCondensed matter physics

摘要: Biodegradable amphiphilic multi-block poly(ether-ester-urethane)s were prepared by one-step bulk polycondensation of PEG and PCL macro-diols HMDI. For biomedical or environmental applications the proposed materials, one critical steps is study degradation characteristics under physiological conditions. Different ratios PEG/PCL molecular weights resultant copolymers allowed for tuning their hydrophilicity, as evaluated water uptake measurements. The swelling results further supported microgravimetric measurements performed QCM-D. In vitro hydrolytic biodegradation was carried out different conditions (i.e., in phosphate buffer solution – with without Lipase). Total mineralization presence microorganisms from a sample river observed to follow kinetics, depending upon composition weight copolymer.

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