作者: S. Cometa , I. Bartolozzi , A. Corti , F. Chiellini , E. De Giglio
DOI: 10.1016/J.POLYMDEGRADSTAB.2010.07.007
关键词: Polycaprolactone 、 Swelling 、 Amphiphile 、 Hydrolysis 、 PEG ratio 、 Copolymer 、 Polymer chemistry 、 Materials science 、 Condensation polymer 、 Chemical engineering 、 Biodegradation 、 Materials Chemistry 、 Mechanics of Materials 、 Polymers and Plastics 、 Condensed matter physics
摘要: Biodegradable amphiphilic multi-block poly(ether-ester-urethane)s were prepared by one-step bulk polycondensation of PEG and PCL macro-diols HMDI. For biomedical or environmental applications the proposed materials, one critical steps is study degradation characteristics under physiological conditions. Different ratios PEG/PCL molecular weights resultant copolymers allowed for tuning their hydrophilicity, as evaluated water uptake measurements. The swelling results further supported microgravimetric measurements performed QCM-D. In vitro hydrolytic biodegradation was carried out different conditions (i.e., in phosphate buffer solution – with without Lipase). Total mineralization presence microorganisms from a sample river observed to follow kinetics, depending upon composition weight copolymer.