Modulating prime molecular expressions and in vitro wound healing rate in keratinocyte (HaCaT) population under characteristic honey dilutions.

摘要: Abstract Ethnopharmacology relevance In traditional medicines honey is known for healing efficacy and vividly used as “Anupan” in Ayurvedic appreciating roles dilutions. Validating of physico-chemically characterized dilutions, studies on vitro wound attainment cellular confluence epithelial cells including expressions cardinal genes crucial. To evaluate effects varied dilutions viability, modulation prime gene expressions. Materials methods Six Indian honey-samples from different sources were optimal one was explored (v/v%) through human (HaCaT) p63, E-cadherin, β-catenin, GnT-III GnT-V. Results Studied samples (i.e. A–F) depicted range pH (2–4), water (12.48–23.95), electrical conductivity (2.57–14.34), carbohydrate (68.73–98.65), protein (.316–5.36) antioxidant potential. Though sample A F showed physico-chemical proximity, but overall bio-impact the earlier better, thus studied 8–.1% (v/v) dilution range. Four (.01, .04, .1, .25 v/v%) augmented viability fastest (p Conclusion Present study illustrated particular (.1%) with characteristic free radical scavenging activity facilitating cell proliferation towards faster (viz. Gnt-III V).