Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders.

摘要: Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass limitations of systemic chemotherapy use in treatment canine brain tumours. Gliomas, which are common dogs and also represent majority fatal tumours humans, can be amenable with temozolomide. Biopolymer microcylinders conjugated temozolomide gadolinium were implanted into partially resected four client-owned gliomas. All presented generalized seizures had mild no neurologic deficits at time craniotomy. underwent craniotomy for implantation gliomas (glioblastoma multiforme {n = 1} or oligodendroglioma 3}). recovered well from procedure. This novel procedure appears feasible tolerated tumour-bearing dogs. A future controlled clinical study now aim evaluate long-term efficacy.