Gender, race/ethnicity, personality, and interleukin-6 in urban primary care patients.

摘要: Abstract Gender, race/ethnicity, and personality are markers of significant psychosocial biological variability. Each may have implications for allostatic load resulting inflammatory processes, yet findings been largely mixed. We investigated whether women, minorities, those higher in Neuroticism lower Extraversion were at risk elevated circulating levels the pro-inflammatory cytokine interleukin (IL)-6 a sample 103 middle aged older urban primary care patients. Regression analyses controlling age, education, current depression levels, chronic medical conditions revealed that individuals had IL-6. Analyses more specific traits sociability positive emotions components unassociated with IL-6, but activity facet—reflecting dispositional vigor energy—was robustly associated The difference between high (+1 Standard Deviation (SD)) low (−1 SD) trait was sufficient to shift IL-6 beyond previously established cut-point both white minority women. These suggest while broad group differences genders races/ethnicities exist, represents an important source individual inflammation within groups. Future work should examine what extent linked temperament or genetic vs. physical itself, be reduced by boosting regular demographic segments such as women minorities who appear susceptible greater inflammation.