Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development.
作者： Ji-Yeob Choi , Josef Abel , Thomas Neuhaus , Yon Ko , Volker Harth
DOI: 10.1097/00008571-200302000-00002
关键词: Oncology 、 Breast cancer 、 Family history 、 Population 、 Endocrinology 、 Breast disease 、 Population study 、 Genotype 、 Cancer 、 Medicine 、 Internal medicine 、 Genotype frequency
摘要: Objective We examined the potential association between alcohol consumption and genetic polymorphisms in metabolizing enzymes, CYP2E1 ALDH2, individual susceptibility to breast cancer a Korean study population. Methods Three hundred forty-six histologically confirmed patients 377 controls with no present or previous history of were recruited from several teaching hospitals Seoul during 1995-2001. The RsaI polymorphism was determined by real time PCR method, ALDH2 Glu487 Lys method confronting two-pair primers (PCR-CTPP). Results drinking women had 1.4-fold risk for (95% CI = 0.99-2.11) compared never drinkers after adjustment age family cancer. No statistically significant overall differences seen genotype frequencies cases controls. However, "ever"-drinking c2 allele containing genotypes 1.9-fold 0.99-3.83) developing non-drinkers c1/c1 (P interaction 0.043). Conclusion This therefore suggests that may influence alcohol-consuming women.
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sci-hub.se 参考文章(37)
H. Werner Goedde, Dharam P. Agarwal, Polymorphism of aldehyde dehydrogenase and alcohol sensitivity. Enzyme. ,vol. 37, pp. 29- 44 ,(1987) , 10.1159/000469239
Neil E. Caporaso, Benjamin F. Trump, Haruhiko Sugimura, Shunji Kato, Curtis C. Harris, Ainsley Weston, Peter G. Shields, Robert N. Hoover, Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer risk. Cancer Research. ,vol. 52, pp. 6712- 6715 ,(1992)
Irene Persson, Inger Johansson, Helene Bergung, Marja-Liisa Dahl, Janeric Seidegård, Ragnar Rylander, Agneta Rannug, Johan Högberg, Magnus Ingelman Sundberg, Genetic polymorphism of cytochrome P4502E1 in a Swedish population : relationship to incidence of lung cancer FEBS Letters. ,vol. 319, pp. 207- 211 ,(1993) , 10.1016/0014-5793(93)80547-8
Ingolf Cascorbi, Jürgen Brockmöller, Ivar Roots, Reinhold Kerb, Combined Analysis of Inherited Polymorphisms in Arylamine N-Acetyltransferase 2, Glutathione S-Transferases M1 and T1, Microsomal Epoxide Hydrolase, and Cytochrome P450 Enzymes as Modulators of Bladder Cancer Risk Cancer Research. ,vol. 56, pp. 3915- 3925 ,(1996)
F Rothhammer, D P Agarwal, H W Goedde, R Lisker, J O Whittaker, S Harada, Aldehyde dehydrogenase polymorphism in North American, South American, and Mexican Indian populations. American Journal of Human Genetics. ,vol. 38, pp. 395- 399 ,(1986)
Shin-ichi Hayashi, Junko Watanabe, Kaname Kawajiri, Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. Journal of Biochemistry. ,vol. 110, pp. 559- 565 ,(1991) , 10.1093/OXFORDJOURNALS.JBCHEM.A123619
Junko Watanabe, Shin-ichi Hayashi, Kaname Kawajiri, Different Regulation and Expression of the Human CYP2E1 Gene Due to the RsaI Polymorphism in the 5'-Flanking Region. Journal of Biochemistry. ,vol. 116, pp. 321- 326 ,(1994) , 10.1093/OXFORDJOURNALS.JBCHEM.A124526
D W Crabb, H J Edenberg, W F Bosron, T K Li, Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. Journal of Clinical Investigation. ,vol. 83, pp. 314- 316 ,(1989) , 10.1172/JCI113875
Mumtaz Iscan, Tuula Klaavuniemi, Tulay Çoban, Nilgun Kapucuoğlu, Olavi Pelkonen, Hannu Raunio, The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. Breast Cancer Research and Treatment. ,vol. 70, pp. 47- 54 ,(2001) , 10.1023/A:1012526406741
Vessela Nedelcheva Kristensen, Elin H Kure, Bjørn Erikstein, Nobuhiro Harada, Anne-Lise Børresen-Dale, Genetic susceptibility and environmental estrogen-like compounds. Mutation Research. ,vol. 482, pp. 77- 82 ,(2001) , 10.1016/S0027-5107(01)00212-3