Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer
作者： Mariko Yamagishi , Masao Noda , Yoichi Tatsumi , Ken-ichi Mukaisho , Shoji Mitsufuji
DOI: 10.1007/S00535-004-1463-1
关键词: Cyclooxygenase 、 Tumor progression 、 Cancer 、 Gastrointestinal cancer 、 Medicine 、 Immunohistochemistry 、 Surgical oncology 、 Mucin 、 Stomach 、 Pathology
摘要: Background Recent studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal cancer, and cyclooxygenase-2 (COX-2) may be a target enzyme for prevention or regression cancer by use NSAIDs. Mucin histochemistry has made possible clear distinction between differentiated characteristics epithelial cells, possibility phenotypic shifts from gastric- to intestinal-type in gastric carcinoma progression been suggested. To evaluate role COX-2 progression, we immunohistochemically investigated expression, examined its relationship proliferative activity, mucin phenotype, clinicopathological parameters human advanced carcinomas.
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