Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

作者: SunHwa Hong , Young-Wook Cho , Li-Rong Yu , Hong Yu , Timothy D Veenstra

DOI: 10.1073/PNAS.0707292104

关键词: BiochemistryHistone methyltransferaseEZH2Histone lysine methylationHistone methylationHistone codeHistone H3MethylationBiologyHistone Demethylases

摘要: … of histone H3 (H3K27) are associated with gene repression (… of H3K27 (H3K27me3) is considered an epigenetic mark … , Polycomb-mediated gene silencing, and X chromosome inacti…

参考文章(26)
Anke Sparmann, Maarten van Lohuizen, Polycomb silencers control cell fate, development and cancer Nature Reviews Cancer. ,vol. 6, pp. 846- 856 ,(2006) , 10.1038/NRC1991
Robert J. Klose, Eric M. Kallin, Yi Zhang, JmjC-domain-containing proteins and histone demethylation. Nature Reviews Genetics. ,vol. 7, pp. 715- 727 ,(2006) , 10.1038/NRG1945
Zhongzhou Chen, Jianye Zang, Johnathan Whetstine, Xia Hong, Foteini Davrazou, Tatiana G. Kutateladze, Michael Simpson, Qilong Mao, Cheol-Ho Pan, Shaodong Dai, James Hagman, Kirk Hansen, Yang Shi, Gongyi Zhang, Structural Insights into Histone Demethylation by JMJD2 Family Members Cell. ,vol. 125, pp. 691- 702 ,(2006) , 10.1016/J.CELL.2006.04.024
Brian D. Strahl, C. David Allis, The language of covalent histone modifications. Nature. ,vol. 403, pp. 41- 45 ,(2000) , 10.1038/47412
Yujiang Shi, Fei Lan, Caitlin Matson, Peter Mulligan, Johnathan R. Whetstine, Philip A. Cole, Robert A. Casero, Yang Shi, Histone demethylation mediated by the nuclear amine oxidase homolog lsd1 Cell. ,vol. 119, pp. 941- 953 ,(2005) , 10.1016/J.CELL.2004.12.012
Yu-Jiang Shi, Caitlin Matson, Fei Lan, Shigeki Iwase, Tadashi Baba, Yang Shi, Regulation of LSD1 histone demethylase activity by its associated factors Molecular Cell. ,vol. 19, pp. 857- 864 ,(2005) , 10.1016/J.MOLCEL.2005.08.027
N. C. Tolga Emre, Stuart L. Schreiber, Jane Mellor, Tony Kouzarides, Helena Santos-Rosa, Robert Schneider, Andrew J. Bannister, Julia Sherriff, Bradley E. Bernstein, Active genes are tri-methylated at K4 of histone H3 Nature. ,vol. 419, pp. 407- 411 ,(2002) , 10.1038/NATURE01080
David J Seward, Gabrielle Cubberley, Soojin Kim, Matt Schonewald, Lian Zhang, Brian Tripet, David L Bentley, Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins Nature Structural & Molecular Biology. ,vol. 14, pp. 240- 242 ,(2007) , 10.1038/NSMB1200
Min Gyu Lee, Christopher Wynder, Neil Cooch, Ramin Shiekhattar, An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation Nature. ,vol. 437, pp. 432- 435 ,(2005) , 10.1038/NATURE04021
Eric Metzger, Melanie Wissmann, Na Yin, Judith M Müller, Robert Schneider, Antoine HFM Peters, Thomas Günther, Reinhard Buettner, Roland Schüle, None, LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature. ,vol. 437, pp. 436- 439 ,(2005) , 10.1038/NATURE04020