Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins
作者： David J Seward , Gabrielle Cubberley , Soojin Kim , Matt Schonewald , Lian Zhang
DOI: 10.1038/NSMB1200
关键词: Histone H2A 、 Biology 、 Chromatin 、 Histone H3 、 Chromatin remodeling 、 Demethylation 、 Protein degradation 、 Cell biology 、 In vivo 、 Methyltransferase
摘要: Histone H3 Lys4 trimethylation (H3-K4me3) is a conserved mark of actively transcribed chromatin. Using conditional mutant the yeast H3-K4 methyltransferase, Set1p, we demonstrate rapid turnover H3-K4me3 and H3-K4me2 in vivo show this process requires Yjr119Cp, JARID1 family JmjC proteins. Ectopic overexpression mouse Jarid1B, Yjr119Cp homolog, greatly diminished HeLa cells, suggesting these proteins function as K4 demethylases vivo.
nature.com
sci-hub.se 参考文章(18)
Paul J. McLaughlin, Robin C. Allshire, Sarah C. Trewick, Methylation: lost in hydroxylation? EMBO Reports. ,vol. 6, pp. 315- 320 ,(2005) , 10.1038/SJ.EMBOR.7400379
Julie Sollier, Waka Lin, Christine Soustelle, Karsten Suhre, Alain Nicolas, Vincent Géli, Christophe de La Roche Saint-André, Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression The EMBO Journal. ,vol. 23, pp. 1957- 1967 ,(2004) , 10.1038/SJ.EMBOJ.7600204
Robert J. Klose, Eric M. Kallin, Yi Zhang, JmjC-domain-containing proteins and histone demethylation. Nature Reviews Genetics. ,vol. 7, pp. 715- 727 ,(2006) , 10.1038/NRG1945
Keith Tan, Anthony L. Shaw, Bente Madsen, Kirsten Jensen, Joyce Taylor-Papadimitriou, Paul S. Freemont, Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. Journal of Biological Chemistry. ,vol. 278, pp. 20507- 20513 ,(2003) , 10.1074/JBC.M301994200
Zhongzhou Chen, Jianye Zang, Johnathan Whetstine, Xia Hong, Foteini Davrazou, Tatiana G. Kutateladze, Michael Simpson, Qilong Mao, Cheol-Ho Pan, Shaodong Dai, James Hagman, Kirk Hansen, Yang Shi, Gongyi Zhang, Structural Insights into Histone Demethylation by JMJD2 Family Members Cell. ,vol. 125, pp. 691- 702 ,(2006) , 10.1016/J.CELL.2006.04.024
B. D. Strahl, R. Ohba, R. G. Cook, C. D. Allis, Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 14967- 14972 ,(1999) , 10.1073/PNAS.96.26.14967
Yujiang Shi, Fei Lan, Caitlin Matson, Peter Mulligan, Johnathan R. Whetstine, Philip A. Cole, Robert A. Casero, Yang Shi, Histone demethylation mediated by the nuclear amine oxidase homolog lsd1 Cell. ,vol. 119, pp. 941- 953 ,(2005) , 10.1016/J.CELL.2004.12.012
Robert Schneider, Andrew J. Bannister, Fiona A. Myers, Alan W. Thorne, Colyn Crane-Robinson, Tony Kouzarides, Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nature Cell Biology. ,vol. 6, pp. 73- 77 ,(2004) , 10.1038/NCB1076
Yu-ichi Tsukada, Jia Fang, Hediye Erdjument-Bromage, Maria E. Warren, Christoph H. Borchers, Paul Tempst, Yi Zhang, Histone demethylation by a family of JmjC domain-containing proteins Nature. ,vol. 439, pp. 811- 816 ,(2006) , 10.1038/NATURE04433
Paul A. C. Cloos, Jesper Christensen, Karl Agger, Alessio Maiolica, Juri Rappsilber, Torben Antal, Klaus H. Hansen, Kristian Helin, The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 Nature. ,vol. 442, pp. 307- 311 ,(2006) , 10.1038/NATURE04837