Stem Cell Epigenetics and Human Disease

摘要: Embryonic stem cells (ESCs) and induced pluripotent (iPSCs) can self-renew to generate more have the ability differentiate into diverse specialized cell types of adult organism. Stem-cell-based therapeutic approaches hold tremendous promise for treatment human diseases. In past few years, several studies aimed elucidate crucial role epigenetic regulatory signals in maintenance potency, but exact underlying mechanisms not been completely understood. Among factors, chromatin dynamics conformation found contribute substantially conservation pluripotency regulation differentiation embryonic (ESCs). Modifications such as histone bivalents remodeling, covalent acetylation methylation, DNA methylation profound effects on cells. Studies ESCs revealed that genes associated with early development are organized within a bivalent structure. This is thought be “poised yet repressed” state, which activated upon differentiation. The breakthrough iPSCs has opened new era biology. During reprogramming, state somatic reorganized an configuration via mostly undetermined mechanism. Up now, numerous disorders modeled vitro through derivation from patients’ subsequent related affected Since changes key factors health disease, there hope understanding mechanism epigenome will aid effective diseases near future.