Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission

摘要: Background: The prevalence of vitamin D deficiency in nursing home patients is high. Objective: We aimed to ascertain whether lower serum 25hydroxyvitamin [25(OH)D] concentrations increase the risk future admission and early death. Design: included 1260 independent, community-dwelling persons aged 65 y who were participating Longitudinal Aging Study Amsterdam (1995–1996). outcomes time durin g6yo ffollow-up death until 1 April 2003. Results: Vitamin [25(OH)D 25 nmol/L] insufficiency[25(OH)D25–49.9nmol/L]werepresentin127(10.1%) 462 (36.7%) subjects, respectively. During follow-up, 138 subjects (11.0%) admitted homes, 380 (30.2%) died. for participants with25(OH)Ddeficiencywas53casesper1000person-yearshigher thanthatforthosewithhigh25(OH)D(75nmol/L)concentrations (58 compared with 5 cases). After adjustment potential confounders, hazard ratio (95% CI) was 3.48 (1.39, 8.75) D–deficient, 2.77 (1.17, 6.55) vitaminD–insufficient,and1.92(0.79,4.66)forvitaminD–borderline as high 25(OH)D (P trend0.002).Theresultsremainedafteradditionaladjustmentfor frailty indicators. Lower associated higher mortality risk, but this association not significant after Conclusion: older are a greater may be mortality. Am J Clin Nutr 2006;84:616–22.